The active ingredient in grapefruit can inhibit the activity of liver drug metabolizing enzyme, many drugs have to go through the final hepatic drug metabolism enzymes eliminated from the body. If you take these drugs while eating a grapefruit, the drug is not metabolized and accumulate in the body and may cause efficacy is too strong, not only affects the treatment, and adverse reactions may occur.
Antihypertensive drugs: Because grapefruit itself also has antihypertensive effect, plus it also enables antihypertensive drugs increased plasma concentration, nifedipine, nimodipine, verapamil and other antihypertensive drugs during eating grapefruit or drinking grapefruit juice, such as drug overdose, blood pressure sudden drop in, ranging from dizziness, palpitation, fatigue, weight is induced angina, myocardial infarction or cerebral apoplexy.
Lipid-lowering drugs: If taking atorvastatin, lovastatin, simvastatin and other lipid-lowering drugs during eating grapefruit, patients with muscle pain, rhabdomyolysis may increase the likelihood of serious cases of acute renal failure may occur.
Sedative sleeping pills: grapefruit will increase diazepam (Valium), midazolam and other drugs likely cause dizziness and drowsiness, high-altitude workers and drivers during the treatment with particular attention.
Contraceptives: grapefruit will hinder the absorption of women on the contraceptives. Women taking birth control pills after sex if eating grapefruit, may lead to contraceptive failure.
Immunosuppressive drugs: grapefruit can immunosuppressants such as cyclosporine blood increased concentration, increased liver and kidney toxicity. If these drugs long-term and grapefruit and other fruits to eat, there is the danger of induced tumors.
Allergy medication: grapefruit of terfenadine may induce adverse reactions such as allergy, causing dizziness, palpitations, arrhythmia and other symptoms.
For safety reasons, the first three days after taking the medication within 6 hours is best to avoid eating grapefruit or drinking grapefruit related products.
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